Sports CBDs

12/29/2022

12/15/2022

12/13/2022

Cinnamon oil, one of the ingredients in Sports CBDs liniments, is a highly concentrated source of beneficial antioxidants.
Some of the most researched health benefits of cinnamon oil include:

Decreases inflammation
High antioxidant content
Stimulates the immune system
CINNAMALDEHYDE is known to:

Be responsible for Cinnamon’s characteristic warming and comforting scent
Exhibit anti-fungal, anti-bacterial, and anti-microbial properties
CINNAMYL ACETATE is known to:

Enhance circulation, thereby allowing the body and hair to receive the required amounts of oxygen, vitamins, and minerals to sustain the health of each
EUGENOL is known to:
Exhibit anti-septic, anti-inflammatory, and analgesic properties
A study published in 2017 demonstrates how cinnamon bark essential oil can significantly stop the creation of several protein biomarkers that are involved in skin inflammation and tissue remodeling. With it’s anti-inflammatory properties, cinnamon oil can be an effective natural remedy for inflammatory skin concerns like rashes and acne.

Clinical research

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Anti-inflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model

ABSTRACT: The effect of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells has not been elucidated. Therefore, we investigated the activity of a commercially available CBEO in a validated human dermal fibroblast system, a model of chronic inflammation

CONCLUSION: The study shows that CBEO is a promising antiinflammatory agent

Phytother Res. 2017 Jul; 31(7): 1034–1038.

Published online 2017 Apr 26. doi: 10.1002/ptr.5822

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518441/
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Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs.

ABSTRACT: In this study, chemical compositions of hydrodistilled essential oil and anti-inflammatory activities from the twigs of Cinnamomum osmophloeum Kaneh. were investigated for the first time.

CONCLUSION: These findings demonstrated that essential oil of C. osmophloeum twigs have excellent anti-inflammatory activities and thus have great potential to be used as a source for natural health products.

Bioresour Technol. 2008 Jun;99(9):3908-13. Epub 2007 Sep 10.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Anti-inflammation+activities+of+essential+oil+and+its+constituents+from+indigenous+cinnamon+(Cinnamomum+osmophloeum)+twigs.

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Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.

OBJECTIVE: The anti-inflammatory activities of the leaf essential oils and their major compounds from seven provenances of C. osmophloeum are investigated here for the first time.

CONCLUSION: These findings demonstrate that the leaf essential oils and their constituents of C. osmophloeum have excellent anti-inflammatory activities and thus have great potential as a source for natural health products.

Pharm Biol. 2010 Oct;48(10):1130-6. doi: 10.3109/13880200903527728.
https://www.ncbi.nlm.nih.gov/pubmed/20815702

12/01/2022

Arnica, one of the ingredients in Sports CBDs liniments, is a genus of perennial, herbaceous plants in the sunflower family (Asteraceae). Several species, such as Arnica montana and A. chamissonis, contain helenalin, a sesquiterpene lactone that is a major ingredient in anti-inflammatory preparations

Bruises
Fevers
Inflammation
Osteoarthritis
Pain
Skin disorders
Sprains
Clinical Research
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Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial.

BACKGROUND:
Dermatological procedures can result in disfiguring bruises that resolve slowly.

OBJECTIVES:

To assess the comparative utility of topical formulations in hastening the resolution of skin bruising.

CONCLUSIONS:

Topical 20% arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.

Br J Dermatol. 2010 Sep;163(3):557-63. doi: 10.1111/j.1365-2133.2010.09813.x.
https://www.ncbi.nlm.nih.gov/pubmed/20412090

Anti-inflammatory activity of Arnica Montana: preclinical study in animals.

ABSTRACT The anti-inflammatory effect of Arnica Montana was evaluated using acute and chronic inflammation models. In the acute, model, carrageenin-induced rat paw oedema, the group treated with Arnica Montana showed 30% inhibition compared to control. Treatment with Arnica 6cH, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process.

CONCLUSION: In the chronic model, Nystatin-induced oedema, the group treated 3 days previously with Arnica Montana had reduced inflammation 6 h after the inflammatory agent was applied.
When treatment was given 6 h after Nystatin treatment, there was no significant inhibitory effect.
In a model based on histamine-induced increase of vascular permeability, pretreatment with Arnica Montana 6cH blocked the action of histamine in increasing vascular permeability.

Homeopathy. 2004 Apr;93(2):84-7.
https://www.ncbi.nlm.nih.gov/pubmed/28401567
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Assessing the Effectiveness of Arnica Montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results.

Abstract

PURPOSE: The purpose of this study was to provide preliminary data on the potential effectiveness of the combination of topical Arnica Montana and Rhododendron tomentosum in reducing postoperative ecchymosis and edema in a select population of healthy volunteers after oculofacial surgery.

CONCLUSIONS: The preliminary results from this study demonstrate that the combination of topical Arnica Montana and Rhododendron tomentosum may be effective in reducing postoperative ecchymosis and edema after oculofacial surgery.

Ophthalmic Plast Reconstr Surg. 2017 Jan/Feb;33(1):47-52. doi: 10.1097/IOP.0000000000000645.
https://www.ncbi.nlm.nih.gov/pubmed/26863038

11/29/2022

Ingredients of Sports CBDs liniments

Dimethyl sulfoxide (DMSO) is currently used as an alternative treatment for various inflammatory conditions the use of DMSO in arthritis warrants further investigation to ascertain its therapeutic potential.
Widely used as a cellular pe*******on enhancer.

Clinical Research
Dimethyl sulfoxide (DMSO): a review.

Abstract Dimethyl sulfoxide (DMSO) is a very simple compound that has stimulated much controversy in the scientific and popular literature. It is an aprotic solvent. Therapeutic and toxic agents that are not soluble in water are often soluble in DMSO. DMSO has a very strong affinity for water; on exposure to air, pure DMSO is rapidly diluted. DMSO's physiologic and pharmacologic properties and effects are incompletely understood.

Properties that are considered to be particularly important to its therapeutic properties include its own rapid pe*******on and enhanced pe*******on of other substances across biologic membranes;. DMSO's systemic toxicity is considered to be low.

Cornell Vet. 1986 Jan;76(1):61-90.

https://www.ncbi.nlm.nih.gov/pubmed/3510103

Medical use of dimethyl sulfoxide (DMSO).

Dermal application of DMSO seems to provide rapid, temporary, relief of pain in patients with arthritis and connective tissue injuries.

An initial clinical trial in 11 patients tends to support this latter application. DMSO enhances diffusion of other chemicals through the skin, and, for this reason, mixtures of idoxuridine and DMSO are used for topical treatment of herpes zoster in the UK.

Rev Clin Basic Pharm. 1985 Jan-Jun;5(1-2):1-33.
https://www.ncbi.nlm.nih.gov/pubmed/3916302

Dimethyl sulfoxide (DMSO) is a very simple compound that has stimulated much controversy in the scientific and popular literature. Fig. 1 It is an aprotic solvent. Therapeutic and toxic agents that are not soluble in water are often soluble in DMSO. DMSO has a very strong affinity for water; on expo...

11/21/2022

Transdermal CBD gel significantly reduced joint swelling, limb posture scores as a rating of spontaneous pain, immune cell infiltration and thickening of the synovial membrane in a dose-dependent manner.
Conclusions
These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.

Almost 50 million (22.2%) adult Americans over 18 were diagnosed with arthritis in 2007–2009, most prominently osteoarthritis and the autoimmune disease rheumatoid arthritis. A projected increase to 67 million is anticipated by 2030 (Centers for Disease Control and Prevention (CDC), 2010). The most effective treatment for rheumatoid arthritis is injectable fusion-proteins which sequester the most prominent proinflammatory cytokine tumour necrosis factor α (TNFα). These chimeric antibodies may halt progression of the disease, but side-effects include immune suppression (Crawford and Curtis, 2008; Furst, 2010; Hastings et al., 2010). Neurogenic drive also contributes to severity of arthritic inflammation (Sluka et al., 1994), and may contribute to its reoccurrence.

More recently, CBD was successfully delivered transdermally in different species for anti-inflammatory activity (Lodzki et al., 2003; Stinchcomb et al., 2004; Paudel et al., 2010). In this study, in vivo efficacy of transdermal CBD delivery to reduce inflammation and pain-related behaviors is tested in a rat adjuvant-induced monoarthritis model with both inflammatory and neurogenic properties (Sluka et al., 1994).

source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/
https://onlinelibrary.wiley.com/doi/10.1002/ejp.818
D.C. Hammell, L.P. Zhang,, F. Ma, S.M. Abshire, S.L. McIlwrath, A.L. Stinchcomb,1 and K.N. Westlund
Eur J Pain. 2016 Jul; 20(6): 936–948.

11/15/2022

Organic Black Pepper Essential Oil
Black Pepper is the common condiment in your kitchen. Traditionally used in Ayurveda Remedies. Many established societies use black pepper in a remedial way.

Reduces Inflammation.
Rich in Vitamins and Minerals.
Rich in Antioxidants.
Enhances Nutrient Absorption.
The Beta Caryophyllene is the compound that increases absorption

Clinical Research
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β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties

BCP and BCPO have strong wooden odor and they are used as cosmetic and food additives. These two natural substances are approved as flavorings by the Food and Drug Administration (FDA) and by the European Food Safety Authority (EFSA) Both compounds exhibit low water solubility, thereby the aqueous medium such as biological fluids, impede their absorption to the cell.

However, it was shown that both BCP and BCPO are able to interact with artificial lipid bilayer, which strongly suggests their high affinity to the cell membrane 1. The potential obstacles associated with poor solubility of these sesquiterpenes in aqueous fluids may be overcome through usage of liposomal drug delivery system, which provides much higher bioavailability of these compounds and by that ensures obtaining desired biological effects.

CONCLUSION: We have presented in this review that natural products, BCP(O), have strong potential for being used in medical applications, due to their anticancer and analgesic properties

In response to pain stimuli, BCP and BCPO reveal different mode of actions. BCP‐induced effect of analgesia is obtained with endocannabinoid system (ECS) involvement, while BCPO analgesic activity is ECS independent. BCP binds to peripheral cannabinoid receptor type 2 (CB 2) leading to β‐endorphin release from keratinocytes and activation of opioid receptors. In contrast, antipain effects of BCPO are possibly achieved by inhibition of central pain receptors. Additionally, both compounds inhibit the release of inflammatory mediators of pain.

Cancer Med. 2016 Oct; 5(10): 3007–3017.
Published online 2016 Sep 30. doi: 10.1002/cam4.816
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083753/ -bib-0002
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Essential Oils from Neotropical Piper Species and Their Biological Activities

BACKGROUND: The Piper genus is the most representative of the Piperaceae reaching around 2000 species distributed in the pantropical region. In the Neotropics, its species are represented by herbs, shrubs, and lianas, which are used in traditional medicine to prepare teas and infusions. Its essential oils (EOs) present high yield and are chemically constituted by complex mixtures or the predominance of main volatile constituents.

CONCLUSION: Piper glabratum leaf . Anti-inflammatory activity was detected by inhibition of leukocyte migration and the protein extravasation into the pleural exudates with no clinical signs of toxicity.

vicosanum EO minimized edema formation and inhibited leukocyte migration using the carrageenan-induced edema and pleurisy The oil displayed a pronounced anti-inflammatory potential, with no acute toxicity or genotoxicity;
The P. aleyreanum EO was tested for antinociceptive activity on two phases of pain model, early neurogenic and the second inflammatory. The effect was significantly more pronounced on the second phase.

Int J Mol Sci. 2017 Dec; 18(12): 2571.
Published online 2017 Dec 14. doi: 10.3390/ijms18122571
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751174/