09/09/2026
Creatine is much more than a muscle supplement.
The research on creatine's cognitive benefits has been quietly accumulating for years, but the marketing has firmly targeted gym rats. Neurons rely on phosphocreatine for rapid ATP regeneration. Research suggests, the same energy mechanism that sustains the last rep in the gym also sustains focus under sleep deprivation, cognitive load, and complex problem-solving.
The brain is metabolically expensive and phosphocreatine is one of the fastest energy-restoration systems it has access to. In published research of cognitive performance under stress and sleep restriction, supplemental creatine has shown measurable effects on processing speed and working memory.*
Then there's the methylation angle, which is where the supplement gets genuinely interesting for anyone tracking dirty genes. The body synthesizes creatine internally, and creatine biosynthesis is one of the largest single consumers of methyl groups in the body. Every unit of creatine the body builds from scratch costs methyl groups that could otherwise go to neurotransmitter synthesis, DNA methylation, phosphatidylcholine production, or detoxification.
Supplementing creatine directly can mean the body simply doesn't need to make as much of its own, so the methyl groups that used to go toward building creatine from scratch become available for everything else.*
For people with MTHFR variants or any reduced methylation capacity, this reframes what creatine is even doing — the cognitive benefit and the methylation support are the same mechanism.*
Dr. Lynch built this same cofactor logic into a new capsule format, for anyone who'd rather not measure out a scoop.
Comment CAPS below to learn more about how creatine supports the brain and get a first look at the new capsules.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.